T.Y.B.Sc. (CHEMISTRY)REVISED SYLLABUS FROM JUNE 2010(SEMESTER SYSTEM)STRUCTURE OF THE SYLLABUSFIRST TERM (SEMESTER III)COMPULSORY COURSESCOURSE NO.TITLECH-331CH-332CH-333CH-334CH-335PHYSICAL CHEMISTRYINORFANIC CHEMISTRYORGNIC CHEMISTRYANALYTICAL CHEMISTRYINDUSTRIAL CHEMISTRYOPTIONAL 36-ENUCLEAR CHEMISTRYPOLYMER CHEMISTRYBIO-CHEMISTRYENVIRONMENTAL CHEMISTRYAGRICULTURE CHEMISTRYSECOND TERM (SEMESTER-IV)COMPULSORY COURSESCH-341CH-342CH-343CH-344CH-345PHYSICAL CHEMISTRYINORGANIC CHEMISTYORGAMIC CHEMISTRYANALYTICAL CHEMISTRYINDUSTRIAL CHEMISTRY
OPTIONAL 46-ENUCLEAR CHEMISTRYPOLYMER CHEMISTRYBIO-CHEMISTRYENVIRONMENTAL CHEMISTRYDAIRY CHEMISTRYPRACTICAL COURSESCH-347CH-348CH-349PHYSICAL CHEMISTRY PRACTICALSINORGANIC CHEMISTRY PRACTICALSORGANIC CHEMISTRY PRACTICALSNOTE:-----1. Each theory paper will carry 50 Marks out of which 10 Marks will be allotted forinternal assessment and University Examination will be conducted for 40 Marks atthe end of each semester.2. The practical examination will be conducted at the end of Semester-IV. Each practicalcourse will carry 100 Marks out of which 20 Marks will be allotted for internalassessment and University Examination will be conducted for 80 Marks.3. Marks for internal assessment of Practical courses will be allotted asfollows.a. Completed and certified journal10 Marksb. Overall performance and regularityof the student during whole academic year 10 Marks4. Internal assessment for theory courses will be done on the basis of the performance ofthe student in tests. Minimum two tests should be arranged for each courses in aSemester.
T.Y.B.Sc. ChemistryCH-331, SemIIIPhysical Chemistry1. Kinetics of Homogeneous Reactions (14)- molecularity and order,- First order reactions and its characteristics,- Second order reactions (with equal and unequal initial concentrations) and itscharacteristics,- Third order reactions (with equal initial concentrations) and its characteristics,- Pseudomolecular reactions,- Effect of temperature on rate of reaction,- The energy of activation.References:1. Principles of Physical Chemistry,4th edition by S.H. Marron and C.F.Pruton2. Adsorption(08)- Adsorption phenomenon- Adsorption of gases by solids,- Types of adsorption,- Adsorption isotherm - Freundlich and Langmuir ,- Adsorption of solute by solids,- Applications of adsorption,- Catalysis of gaseous reactions by solid surfaces,- One reactant gas slightly, moderately and strongly adsorbed- Retarded reactions- The order of heterogeneous reactions.References :1. Principles of Physical Chemistry,4th edition by S.H.Maron and C.F.Proton3. Crystal Structure (10)- Crystallization and fusion process,- Crystallography, Crystal systems,- Properties of crystals,- Crystal lattice and unit cell,- Crystal structure analysis by X ray - The Laue method and Braggs method,- X-ray analysis of NaCl crystal system,- Calculation of d and λ for a crystal system.Reference1.Principles of Physical Chemistry,4th edition , by S.H. Marron and C.F.Pruton
4. Investigations of molecular structure (16L)- Molar refraction,- Electrical polarization of molecules,- Permanent dipole moment,- Determination of dipole moment,- Molecular spectra - Rotational, vibrational and Raman spectraReference2. Molecular SpectroscopyC.N.Banwell, 3rd editionPages- 1-15, ------------ ReferenceBooks1.Principles of Physical Chemistry,4th edition by S.H. Marron and C. F. Pruton2. Molecular SpectroscopyC. N. Banwell, 3rd edition3.4.University general Chemistry,C.N.R.Rao, Mc MillanElements of Physical Chemistry,G.M. Barrow,Mc Graw Hill Publication
T.Y.B.Sc. ChemistryCH-341, Sem IVPhysical Chemistry1. Electrolytic conductance (12L)- Recapitulation of Electrolytic conductance,- Specific and equivalent conductance,- Variation of equivalent conductance with concentration,- Kohlrausch’s law and its applications to determinei)Equivalent conductance at infinite dilution of a weak electrolyte,ii)The ionic product of water,iii)Solubility of sparingly soluble salts,- Migration of ions and ionic mobilities, absolute velocity of ions- Transport number determination by Hittorf;s method and moving boundary method,- Relation between ionic mobility, ionic conductance and transport number,- Ionic theory of conductance,- Debye-Huckel –Onsager equation and its validity,- Activity in solution, fugacity and activity coefficient of strong electrolyte,References1. Pages: 398-4372. Electrochemical cells (14 L)- Reversible and irreversible cells,- Emf and its measurements,- Standard cells, cell reaction and Emf,- Single electrode potential and its calculation,- Calculation of cell Emf,- Thermodynamics of cell Emf,- Types of electrodes,- Classification of electrochemical cells with and without transference,- Applications of Emf measurmenti)Solubility product of sparingly soluble salt,ii)Determination of pH,iii)Potentiometric titrationReferences1. Pages: 471-486, 492-519.3. Nuclear Chemistry (12 L)- The atom, nucleus and outer sphere, classification of nuclides, nuclear stability andbinding energy.- Discovery of radioactivity, types of radioactivity, general characteristics of radioactivedecay and decay kinetics,- Measurements radioactivity, gaseous ion collection method, proportional andG.M.Counter,- Applications of radioactivityRadiochemical principles in the use of tracers,Typical applications of radioisotopes as a traceri) Chemical investigations- reaction mechanism ,
ii) Sructure determination- phosphorus pentachloride and thiosulphate ioniii) Age determination- dating by 3H and 14C content,iv) Medical applicationsReferences:2. pages 1, 4-15, 117-119,121-125,371-378,3. pages 243-245,247-251,4. pages 198-2094. Elements of Quantum Chemistry:(10 L)concept of quantization, atomic spectra (no derivation), wave particle duality,uncertainty principle, wavefunction and its interpretation, well-behaved function,Hamiltonian (energy) operator, formulation of Schrodinger equation, particle in box(1D, 2D and 3D box) (no derivations), sketching of wavefunction and probabilitydensities for 1D box, correspondence principle, degeneracy, applications toconjugated systems, Jahn teller effect and energies of 3 D box (lifting of degeneracy),harmonic oscillator, wavefunction and probability densities (no derivation), zero pointenergy and quantum tunneling.Reference5.Physical Chemistrya molecular approachby Donald A. McQuarrie , John D. SimonReferences:1. Principles of Physical Chemistry,Fourth Edition by S.H. Marron and C. F. Pruton2. Essentials of Nuclear Chemistry,H.J.Arnikar Second edition3. Nuclear and radiation Chemistry, Third edition4. Quantum Chemistry second editionby Manas Chandra5.Physical Chemistry a molecular approachby Donald A. McQuarrie , John D. Simon
T.Y.B.Sc.126.96.36.199.188.8.131.52.Physical Chemistry PracticalsCH- 347Chemical Kinetics (any five)To study the effect of concentration of the reactants on the rate of hydrolysis ofan ester.To compare the relative strength of HCl and H2SO4 by studying the kinetics ofhydrolysis of an ester.To compare the relative strength of HCl and H2SO4 by studying the kinetics ofInversion of cane sugar using Polarometer.To study the kinetics of iodination of acetoneTo determine the first order velocity constant of the decomposition of hydrogen peroxideby volume determination of oxygen.To determine the energy of activation of the reaction between potassium iodide andpotassium persulphate.To determine the order of reaction between K2S2O8 and KI by equivalent method.2. ViscosityTo determine the molecular weight of a high polymer by using solutions of differentconcentrations.3AdsorptionTo investigate the adsorption of oxalic acid /acetic acid by by activated charcoal and test thevalidity of Freundlich / Langmuir isotherm4. Phenol-water systemTo study the effect of addition of salt on critical solution temperature of phenol waterSystem5. Transport numberTo determine the transport number of cation by moving boundry method .6. Refractometry (any two)i)To determine the specific refractivities of the given liquids A and B and theirmixture and hence determine the percentage composition their mixture C.ii)To determine the molecular refractivity of the given liquids A,B,C and D.iii)To determine the molar refraction of homolouges methyl, ethyl and propyl alcoholand show the constancy contribution to the molar refraction by -CH2 group.Group B1. Colorimetry (any two)i) Determination of λmax and concentration of unknown solution of KMnO4 in 2 NH2SO4ii) Determination of λmax and concentration of unknown solution of CuSO4 .iii) To titrate Cu2 ions with EDTA photometrically ,iv)To determine the indicator constant of methyl red indicator
2.Potentiometry ( any three)i) To prepare standard 0.2 M Na2HPO4 and 0.1 M Citric acid solution, hence preparefour different buffer solutions using them. Determine the Pk value of theseand unknown solutions.ii)To determine Pka value of given monobasic acid by potentiometric titration.iii)To determine the amount of NaCl in the given solution by potentiometric titrationagainst silver nitrate.iv)To determine the formal redox potential of Fe2 / Fe3 system potentriometricallyv)To determine the amount of Cl- and Br- from the given halide mixture by titratingwith silver nitrate solution3. pH metry. (Any two)i)To determine the degree of hydrolysis of aniline hydrochlorideii)To determine Pka value of given weak acid by pH-metric titration with strong base.iii)To determine the dissociation constant of oxalic acid by pH-metric titration withstrong baseiv)To determine pH of various mixtures of sodium acetate and acetic acid in aqueoussolution and hence to find the dissociation of acetic acid.4. Radioactivity. (any one)i)To determine plateau voltage of the given G M counter.ii)To determine the resolving time of GM counteriii)To determine Emax of beta particle5. Conductrometry (any two)i)To determine the cell constant of the given cell using 0.01 M KCl solution andhence determine dissociation constant of a given monobasic weak acid.ii)To estimate the amount of lead present in given solution of lead nitrate byconductometric titration with sodium sulphate.iii)To investigate the conductometric titration of any one of the followinga) Strong acid against strong baseb) Strong acid against weak basec) Strong base against weak acidd) Weak acid against weak baseStructure of practical examination1. One experiment from group-A2. One experiment from group-B3. OralMarks353510
Reference books1. Practical Physical Chemistry 3rd editionA.M.James and F.E. Prichard , Longman publication2. Experiments in Physical ChemistryR.C. Das and B. Behra, Tata Mc Graw Hill3. Advanced Practical Physical ChemistryJ.B.Yadav, Goel Publishing House5. Advanced Experimental Chemistry. Vol-I J.N.Gurtu and R Kapoor,S.Chand and Co.
Inorganic ChemistryPaper – CH-332TopicNo. of Lectures1. Molecular Orbital Theory2. Coordination Chemistry1533481. Molecular Orbital TheoryM.O. Method LCAO principle & Rules of LCAO.Combination of Atomic orbital: S-S, S-P, P-P and d-dNon-bonding combination orbitals.M.O. Energy leveldaigram for homonuclear diatomic molecules.Explaining existence by calculating bond order, energy and magnetic behavior forfollowing molecules or ions H2, H2 , He2 , Li2, Be2, B2, C2, N2, O2, O2 , O2-, O2- -, F2, Ne2M.O. energy level diagram for heteronuclear diatomic molecule like CO, NO, HCl, HF.Ref. 2 page 89-112, 106-117Ref. 4 page 55-72Aims and objective:Student should know:1. Shapes of S,P, d orbital2. Overlap of S-S, S-P, P-P and d-d orbital to form molecular orbitals.3. Comparison ofa) Atomic orbital and molecular orbitalb) BMO and ABMOc) VBT and MOT4. Comparison between BMO, ABMO and n BMO.5. Drawing of molecular orbital and calculate bond order and explain stability of thefollowing molecule and ions.a) H2, H2 , He2 , Li2, Be2, B2, C2, N2, O2, O2 , O2-, O2- -, F2, Ne2b) CO, NO, HCl, HF.
2. Coordination ChemistryI. INTRODUCTION TO COORDINATION CHEMISTRY General account and meaning of the terms involved in coordination chemistry (centralmetal atom or ions, complex compound , complex ion calculation of oxidation number ofmetal, coordination number etc)Ligands: Definition, Classification, Chelates and chelating agents.Formation Constant, inert and labile complexes.IUPAC nomenclatureApplication of complexes in different fields.II. WERNER THEORY OF COORDINATION COPMOPOUNDS AssumptionsStereochemistry of ComplexesIII. ISOMERISM IN COORDINATION COMPLEXES Structural isomerism (ionization, hydrated, linkage ligand, coordination position,polymerization isomers)Geometrical isomerism and optical isomerism.IV. SIDWICK MODEL, EAN RULE LIMITATIONSV. PAULINGS VALENCE BOND THEORY IntroductionAssumptionsConcept of hybridizationBonding in tetrahedral, square planer, trigonal bipyramidalwith examples.Inner and outer orbital complexes.Electro neutrality principleMultiple bondingLimitationsVI. CRYSTAL FIELD THEORY IntroductionAssumptionsDegeneracy of d orbital.and octahedral complexes
Application of CFT to octahedral, tetrahedral, square planer complexesCFSE, calculation of CFSE in weak field and strong field complexes.Evidences of CFSE.Factors affecting 10 DqCFT and magnetic properties :- Spin only magnetic moments equation, electronoccupancy in CFT. Problems related to calculation of spin only magnetic moment foroctahedral, tetrahedral & square plannar complexes. (i.e. for high spin & low spincomplexes)Spectrochemical series.Nephelauxatic effectJohn teller distortion, limitations.VII. MOLECULAR ORBITAL THEORY OF COORDINATION COMPLEX IntroductionAssumptionsMO treatment to octahedral complexes with δ and π bonding, effect of π-bonding.Charge transfer spectra.Comparison of VBT, CFT, & MOT.Ref. 2 pages 194 -236Ref. 8 Relevant pagesRef. 9 Relevant pagesAims and objectiveThe student should:1. Know the various types of Ligands2. Know the meaning of the terms used in co-ordination chemistry3. Be able to name the co-ordination compound when the structure is given to them.4. Know the application of co- ordination compounds in biology and chemistry.5. Be able to draw the geometrical and optical isomerism of complexes.6. Be able to explain various types of isomerism.7. Know the merits and the demerits of Sidwick’s theory8. Know the assumptions of VBT and explain the VBT / and explain the VBT of differentcomplexes.9. Know the limitations of VBT.10. Know outer and inner orbital complexes, electro neutrality principle, multiple bonding11. Be able to draw crystal filled splitting of d orbital of metal ion in octahedral, tetrahedralsquare planer of tetragonal ligand field.12. Know the assumptions of CFT.13. Be able to explain the terms Strong field and weak field splitting.14. Be able to explain magnetic property CFT spectra.
15. Be able to give evidences of CFSE.16. Be able to explain Charge transfer Spectra.17. Be able to explain John- Teller distortion of octahedral complex and its effect onSpectra.18. Be able to compare the different approaches to bonding in Co-ordination compounds.Reference Books:Ref. 1 Introduction to electrochemistry by Glasstone - 2nd edition.Ref. 2 Concise inorganic chemistry by J.D. Lee - 5th edition.Ref. 3 Inorganic Chemistry-D.F. Shiver & P.W. AtkinsC.H.Largeford ELBS - 2nd edition.Ref. 4 Basic Inorganic Chemistry-F.A. Cotton and Wilkinson, Wiely Eastern Ltd 1992.Ref .5 Concept and model of inorganic chemistry by Douglas – Mc Daniels - 3rd edition.Ref. 6 Chemistry by Raymond Chang - 5th editionRef. 7 New guide to modern valence theory by G.I. Brown - 3rd editionRef. 8 Co-ordination Compounds by Baselo and Pearson.Ref. 9 Theoretical Inorganic Chemistry by day and Selbin.Ref.10 Inorganic Chemistry by Sharpe - 3rd Edition
INORGANIC CHEMISTRYPaper CH-342Topic1. Chemistry of f-block element2. Bioinorganic Chemistry3. Organometalic Chemistry4. Metals Semiconductors and Superconductors5. Ionic Solids6. Thermodynamic properties of Co-ordination ComplexesNo. of Lectures080610100608481. Chemistry of f- block elements.I. Lanthanides Position in periodic Table Name electronic Configuration Oxidation States Occurrence and separation (Group/ Individual) by ion exchange and solvent extractionmethod. Lanthanide contraction & its effect on chemistry of Lanthanides and post lanthanideelement. Applications.II. Actinides Position in periodic TableName electronic ConfigurationOxidation StatesOccurrence and general methods of preparation of transition element1. Neutron Bombardment2. Accelerated projectile bombardment.3. Heavy ion bombardment. Nuclear Fuels:1. Nuclear Fusion fuels & nuclear fission fuelsIUPAC nomenclature system for super heavy elements with atomic no. (z) greater than100.
Comparison between Lanthanides and Actinides.Ref. 2 Page 859-863, 865-866, 874 – 875Page 879-886, 891-893, 898-900Aims and objectiveStudents should know:1. Meaning of term f-block elements, Inner transition elements, lanthanides2. Electronic configuration of lanthanides3. Oxidation state s of lanthanides and common oxidation states.4. Use of lanthanide elements in different industries.5. Meaning of Actinide elements their position in periodic table.6. Transuranic elements.7. Preparation methods of Transuranic elements8. Nuclear fuels and their applications.9. Why transuranic elements are called as the synthetic elements?10. IUPAC nomenclature for super heavy elements with atomic no. 100 onwards.2. Bioinorganic Chemistry IntroductionRole of metal in bioinorganic chemistry.Compounds of Ca, Mg, Fe and CoBioinorganic Chemistry of Iron: Heam proteins – hemoglobin and myglobein, Functionsof Oxygen transfer, Fe (II) complex of porphyrin, oxygen binding O2 transfer, partialpressure, pH dependenceNature of oxyheamoglobein & deoxyheamoglobein, geometry of Complex.Vitamin B12 Structure and Applications.Ref. 3 page 782-783, 790-796, 813-815Ref. 2 page 353, 775, 779, 796-797Ref .4 page 553-557, 560-562Aims and objective1. The biological role of inorganic ions & compounds2. Abundance of elements in living system and earth crust.3. Classification of functions of the elements in relation to their biological environment
4. Biological catalysis, metalloids involves in acid catalyzed hydrolysis ( Hydrolyses), redoxreactions (oxidases and isomerase’s ) process that rearrange C-C bonds (synthesis &isomerise)5. Biomolecules containing metal ion that serves as electron carries , metal storage sitesand O2 binding and storage and participate in signal transudation6. Biological role of Mg2 & Ca2 7. Bioinorganic chemistry of iron hemoglobin, myoglobein.8. Photosynthesis structure of Chlorophyll, photo system I & II9. Structure & applications of Vitamin B123. Organometalic Chemistry IntroductionGeneral principleCarbonyl complexesCO most important π ligandBinary carbonyl complexesSynthesis18 electron ruleSolid state structure of some neutral binary metal carbonylHomogeneous catalysis by soluble transition metal complexFeed stock for chemical industryHydroxylation (oxoreaction)Wacker processMonsanto acetic acid synthesisRef. 5 page 561-570, 685-690, 695-696Ref. 6 Related pages4. Metal semiconductor and Super conductors IntroductionBand theory with respect to Na along with n (E) and N(E) diagramsElectrical conductance of metal (Na, Mg, Al)Semiconductors – types of Semiconductors: I. Intrinsic II. ExtrinsicN & P type semiconductors ZnO and NiOSuper conductivityDiscoveryPropertyModels structure and superconductivityApplications
Ref. 7 209-221Ref. 6 Related pagesAims and objectiveA student should know1. Meaning of metal & semiconductor2. Difference between metal semiconductor and insulator3. Metallic bond on the basis of band theory4. Intrinsic and extrinsic semiconductor5. The term valancy band and conduction band6. Drawing of n (E) & N (E) Curves7. n and p type of semiconductors8. Non-stoitiometry and semi conductivity9. Electrical insulators o the basis of band theory10. Difference between properties of Na, Mg, and Al in terms of conductivity11. Meaning of super conductors12. Structure13. Discovery and applications5. Ionic Solids Crystal structure simple cubicVoids in crystal structureIonic radiusPalings univalent and crystal radii (Problems)Radius ratio effect, lattice energy, Born-lande equation Born Haber cycle and itsapplicationsScotty and Frankel’s defectRef. 2 page 32-61Ref. 7 page 55-62Ref. 5 page 102-127
Aims and objectivesA student should know184.108.40.206.5.6.7.Draw the simple cube BCCBe able to solve simple problems based on Pauling’s univalent radii and crystal radii.Be able to explain radius ratio effect and its limitationsKnow how to draw Born-Haber cycle.Be able to solve simple problems as Born- Haber cycleKnow the defects in Ionic solidsBe able to differentiate between the defects.6. Thermodynamic properties of Coordination Complexes CFSE: High spins octahedral complexes.CFSE: Tetrahedral complexes of site preferencesCFSE: Low spin octahedral complexesOxidation states of transition metal complexes in aqueous media.Ionization potential of transition complexesQualitative survey of the substitution of co-ordination complexesReferencesRef. 1 Modern aspects of Inorganic Chemistry- H.J. Emeleus- A.G.SharpePages 505- 532
Reference Books:Ref. 1 Introduction to electrochemistry by Glasstone - 2nd edition.Ref. 2 Concise inorganic chemistry by J.D. Lee - 5th edition.Ref. 3 Inorganic Chemistry-D.F. Shiver & P.W. AtkinsC.H.Largeford ELBS - 2nd edition.Ref. 4 Basic Inorganic Chemistry-F.A. Cotton and Wilkinson, Wiely Eastern Ltd 1992.Ref .5 Concept and model of inorganic chemistry by Douglas – Mc Daniels - 3rd edition.Ref. 6 Chemistry by Raymond Chang - 5th editionRef. 7 New guide to modern valence theory by G.I. Brown - 3rd editionRef. 8 Co-ordination Compounds by Baselo and Pearson.Ref. 9 Theoretical Inorganic Chemistry by day and Selbin.Ref.10 Inorganic Chemistry by Sharpe - 3rd Edition
INORGANIC CHEMISTRY PRACTICALSCH-348A) Gravimetric estimations (Any 3)1. Fe as Fe2O32. Nickel as Ni – DMG3. Al as Aluminum oxide4. Gravimetric estimation of Ba as BaSO4 using homogeneous precipitation method.B) Volumetric Estimations (Any 3)1. Mn by volhard method2. Analysis of Alkali mixture by Volumetric method3. Estimation of % purity of given sample of Sodium Chloride4. Analysis of BrassC) Inorganic preparations (Any 3)220.127.116.11.Preparation of [Ni (NH3) 6] 2 Preparation of Trioxalatoferrate and estimation of oxalate using permagnometry.Preparation of [Cu (NH3) 4] SO4 and estimation of Copper Idometrically.Preparation of Crystals of Potash alum and estimation of aluminum volumetrically.D) Colorimetric Estimations (Any 2)1. Iron2. Cobalt3. Titanium4. Separation of Iron from aqueous solution by solvent extraction using 8-hydroxyquinolinein Chloroform and its colorimetric titration’sE) Separation of binary mixture of cations by Column Chromatography (2 mixtures)F) Qualitative Analysis (6 mixtures including Borates and Phosphates)
STRUCTURE OF PRACTICAL EXAMINATIONExperimentMarks1. Qualitative analysis (Compulsory Experiment)402. Gravimetric ExperimentORVolumetric ExperimentORPreparationORChromatography303. Oral10Reference BooksRef. 1 General Chemistry experiment – Anil J Elias (University press).Ref. 2 Vogel textbook of quantitative chemical analysis G.H. Jeffery, J. Basset.Ref. 3 Quantitative chemical analysis S. Sahay (S. Chand & Co.).Ref. 4 Quantitative analysis R.A. Day, Underwood (prentice Hall).Ref. 5 Practical Chemistry K.K. Sharma, D. S. Sharma (Vikas Publication).Ref. 6 Vogel textbook of quantitative chemical analysis.
University of PuneSyllabus for T. Y. B. Sc.Organic Chemistry (CH-333),First Term Semester III1. Organic Structures, nomenclatures, Properties and Reactivities(08)Introduction, drawing organic molecules, naming organic compounds – use of systematic,(IUPAC), trivial (Common) and acronyms, structural effects and reactivity- Inductive,resonance (mesomeric), steric, hyperconjugation effects, tauto merism, hydrogen bondingand effect of these on strength of acids and bases.Ref. 7 & 8 relevant pages.2.Stereochemistry of disubstituted cyclohexane(07)Introduction,Disubstituted cyclohexane.Type 1:1,1disubstituted cyclohexane,Type2:1,2disubstituted cyclohexane,Type 3:1,3-disubstituted cyclohexane,Type 4:1,4disubstitutedcyclohexane.Geometrical & Optical isomerism,Energy calculations.Ref.1.Relevant pages.3.Nucleophilic substitution at aliphatic Carbon(08)Introduction,Nucleophiles & leaving groups, mechanism of nucleophilic substitution.The ersion).TheSN1reaction:Kinetics,mechanism & stereochemistry(Racemisation),stability of carbocation.How to know whether a given reaction will follow SN1 or SN2 mechnism.Comparision of SN1& SN2 reactions.SNi reactions.Ref.1.Section 5.7 to 5.21,5.23 Pages 172-203 and 208 to 210Ref.8.Relevant pages4.Reactions of Carbon –Carbon double bond & triple bond(08)a)Introduction to Carbon-Carbon double bond reactions.Examples of additionreactions.Mechanism of electrophilic addition to C C bond.Hydrogenation ,Orientation &reactivity,Rearrangements(Support for formation of arbocation).AntiMarkavnokoff’saddition(peroxide effect).Addition of halogens,Addition of hypohalous acids HOX,Oxymercuration –demercuration,Hydroxylation (formation of 1,2- iols).HydroborationOxidation(Formation of alcohol),Hydrogenation (Formation ofalkane), Ozonolysis(formation of aldehyde & tions of Carbon –Carbon triple bond-addition of hydrogen,halogens,halogen acids,water& formation of metal acetylides.Ref.1pages 431-433
5.Reactions of Carbon –Oxygen double bond:(05)Introduction,Structure of carbonyl group,reactivity of carbonyl group,addition ivatives,CannizzaroRef.1.Relevant pagesreaction.6)Oxidation & Reduction reactions(04)a)Oxidation reactions using following reagents.(i)CrO3 (ii)K2Cr2O7 (iii)SeO2 (iv)HIO4b)Reduction reactions using following reagents(i)Sn-HCl (ii)Na-C2H5OH (iii)NaBH4 (iv)LiAl H4.Ref.2.Relevant pages7 . Elimination Reactions(08)a) 1,2- elimination reactionsb) Kinetics of dehydrogenation (duality of Mechanism)c) E2 mechanism with evidences- Isotopic effect, element effect and absence of hydrogenexchange.d) Orientation of E2 Mechanism.e) E1 Mechanism with evidences.f) Orientation of E1 Mechanism.Ref 1-. Section 8.13 to 8.25 pages 290-310Ref 2- Relevant Pages.Reference Books:1) Organic Chemistry by Morrison and Boyd 6th Edn2) Organic Chemistry by Cram and Hammond.3) Stereochemistry of Organic compounds by Eliel Tata Mc Graw Hill 1989.4) Organic Chemistry by John Mc Murry Vth Edn. 19995) Organic Chemistry by Graham solomans6) Organic Chemistry by I.L.Finar Vol.II Vth Edn.7) Organic Chemistry by Clayden, Greeves, Warren and Wothers (Oxferd Press)8) A guide book to reaction Mechanism by Peter Sykes Vth Edn.
Organic Chemistry (CH-343)Semester IV: (Second Tearm)1. Aromatic Electrophilic and Nucleophilic Reactions(10)A) Aromatic Electrophilic substitution reactions:i) Introduction and general Mechanism.ii) Effect of substituent group (Orientation, o/p directing and meta directing groups )iii) Classification of subsitutent groups (activating and deactivating groups)iv) Mechanism of following reactions – Nitration, Sulphonation, Halogenation, Fridel-Craft’sreactions, Diazo Coupling reactions.B) Aromatic Nucleophilic Substitution Reactions- SNAr, Benzyne with Examples.Ref-1 Section 15.1 to 15.19, 16.8, 16.9, 18.5 pages 517-544, 666, 667.Ref -2 Relevant pages.2. Carbanions and their reactionsi) Formation and stability of Carbanionsii) Reactions involving carbanions and their mechanismsa) Aldolb) Claisenc) Dieckmannd) Perkiniii) Synthesis and Synthetic applications ofa) Malonic esterb) Acetoacetic esterc) Wittig reagent.Ref. 2 Relevant Pages(06)3. Retrosynthetic analysis and applications(04)a) Introduction, Different terms used – Disconnection, Sunthon, Synthetic equivalence,FGI, TM.b) One group disconnection with examples.c) Retrosynthesis and Synthesis of Following Target Moleculesi) Acetophenone ii) t-butylalcohol, iiii) Crotonaldehyde iv) Cyclohexene v)Cyclohexene-3-one vi) Benzoin vii) Cyclopentyl methanal viii) Benzylbenzoateix) 2-Phenyl ethylbromide x) Benzyl diethyl malonate.Ref-3- Relevant pages Ref-4. Relevant pages4. Spectroscopic methods in structure determination of Organic compounds (22)A) Introduction: i) Meaning of spectroscopy, nature of electromagnetic radiation, wavelength, frequency, energy, amplitude, wave number, and their relationship, different units ofmeasurement of wavelength frequency, different regions of electromagnetic radiationsii) Interaction of radiation with matter excitation of molecules with different energy levels,such as rotational, vibrational and electronic level.iii) Types of spectroscopy and advantages of spectroscopic methods.Ref-5. Sections 1.2, 1.3, 1.6, 1.7, 1.8, 1.10 pages 1-3, 7-11 or any other standard referencebook.
B) Ultra Violet Spectroscopyi) Introduction, Nature of U.V., Beer’s law, absorption of U.V. radiation by organic moleculeleading to different excitation. Terms used in U.V. SpectroscopyChromophore, Auxochrome, Bathochromic shift, hypsochromic shift, hyperchromic andhypochromic effect.ii) Effect of Conjugation on position of U.V. band.iii) Calculation of max by Woodward and Fiser rules for dienes and enone sustems.iv) Colour and visible spectrum.v) Applications of U.V. Spectroscopy- Determination of structure, Determination of stereochemistry (Cis and trans)Ref-5. Section 2.1, 2.3, 2.7 to 2.15 pages 13-15, 18-38,C) Infra red Spectroscopyi) Introduction, Principle of I.R. Spectroscopy, Fundamental modes of vibrations (3N-6,3N5) Types o