Yun Li Curriculum Vitae February 20, 2017

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Yun LiCurriculum VitaeFebruary 20, 2017CURRICULUM VITAEPERSONAL INFORMATIONName:e-mail:URL:Yun CATIONPhD, University of Michigan, Ann Arbor, MI, 2004-2009, BiostatisticsMS, Bowling Green State University, Bowling Green, OH, 2002-2004, Applied StatisticsMA, Bowling Green State University, Bowling Green, OH, 2001-2002, Communication StudiesB.S., Shanghai Jiaotong University, China, 1997-2001, English (Finance and Business)Second B.S., Shanghai Jiaotong University, China, 1998-2001, Computer and ApplicationPROFESSIONAL EXPERIENCEAssociate Professor of Genetics, UNC, Chapel Hill, NC, 2015Associate Professor of Biostatistics, UNC, Chapel Hill, NC, 2015Adjunct Assistant Professor of Computer Science, UNC, Chapel Hill, NC, 2012Assistant Professor of Genetics, UNC, Chapel Hill, NC, 2009-2015Assistant Professor of Biostatistics, UNC, Chapel Hill, NC, 2009-2015Member, Carolina Center for Genome Sciences, UNC, Chapel Hill, NC, 2009-HONORS AND 6, Faculty Member, Theta Chapter of the Delta Omega SocietyThomson Reuters Highly Cited ResearcherJunior Faculty Development Award, UNCJefferson-Pilot Fellowship in Academic Medicine, School of Medicine, UNCRackham Predoctoral Fellowship, University of MichiganASHG Trainee Award in Predoctoral BasicRackham One-Term Dissertation Fellowship, University of MichiganMarch of Dimes Scholarship on Medical & Experimental Mammalian GeneticsRackham Travel Grant, University of MichiganBest Performance on Qualifying Examination, University of MichiganRobert A. Patton Book Scholarship, Bowling Green State UniversityRonald Benton Scholarship, Toledo Section, American Society for QualityWray Jackson Smith Scholarship, American Statistical AssociationLevel 1 (highest) in International Japanese Proficiency TestAnnual Academic Scholarship, Shanghai Jiaotong UniversityHarler Scholarship for Excellence in German Language Studies1

Yun LiCurriculum VitaeFebruary 20, 20171997-1998: Yan Kuanhu Fund Scholarship for Excellent Performance1997-1998: Scholarship of the Metrobank FoundationBIBLIOGRAPHYRefereed original research:* indicates first or co-first authorship# indicates corresponding authorshipunderscore indicates lab member1. Schmitt AD, Hu M, Jung I, Xu Z, Qiu Y, Tan CL, Li Y, Lin S, Lin Y, Barr CL, Ren B (2016) ACompendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human.Cell Reports 17(8): 2042-2059. PMID: 27851967. (highlighted by Nature Reviews df/nrg.2016.161.pdf)2. Liu C, Marioni RE, Hedman ÅK, Pfeiffer L, Tsai PC, Reynolds LM, Just AC, Duan Q, BoerCG, Tanaka T, Elks CE, Aslibekyan S, Brody JA, Kühnel B, Herder C, Almli LM, Zhi D,Wang Y, Huan T, Yao C, Mendelson MM, Joehanes R, Liang L, Love SA, Guan W, ShahS, McRae AF, Kretschmer A, Prokisch H, Strauch K, Peters A, Visscher PM, Wray NR,Guo X, Wiggins KL, Smith AK, Binder EB, Ressler KJ, Irvin MR, Absher DM, Hernandez D,Ferrucci L, Bandinelli S, Lohman K, Ding J, Trevisi L, Gustafsson S, Sandling JH, Stolk L,Uitterlinden AG, Yet I, Castillo-Fernandez JE, Spector TD, Schwartz JD, Vokonas P, LindL, Li Y, Fornage M, Arnett DK, Wareham NJ, Sotoodehnia N, Ong KK, van Meurs JB,Conneely KN, Baccarelli AA, Deary IJ, Bell JT, North KE, Liu Y, Waldenberger M, LondonSJ, Ingelsson E, Levy D (2016) A DNA methylation biomarker of alcohol consumption. Mol.Psychiatry [Epub ahead of print] PMID: 27843151.3. Xu Z, Zhang G, Wu C, Li Y#, Hu M (2016) FastHiC: a fast and accurate algorithm to detectlong-range chromosomal interactions from Hi-C data. Bioinformatics 32(17):2692-2695.PMID: 27153668. PMCID: PMC5013904.4. Zhang G, Huang KC, Xu Z, Tzeng JY, Conneely KN, Guan W, Kang J, Li Y# (2016)Across-Platform Imputation of DNA Methylation Levels Incorporating Nonlocal InformationUsing Penalized Functional Regression. Genet Epidemiol. 40(4):333-40. PMID: 27061717.PMCID: PMC4862742.5. Xu Z, Zhang G, Duan Q, Chai S, Zhang B, Wu C, Jin F, Yue F, Li Y#, Hu M (2016) HiView:an integrative genome browser to leverage Hi-C results for the interpretation of GWASvariants. BMC Res Notes 9(1): 159. PMID: 26969411. PMCID: PMC4788823.6. Naik RP, Wilson JG, Ekunwe L, Mwasongwe S, Duan Q, Li Y, Correa A, Reiner AP (2016)Elevated D-dimer levels in African Americans with sickle cell trait. Blood 127(18): 2261-3.PMID: 26968536. PMCID: PMC4859200.7. Below JE, Parra EJ, Gamazon ER, Torres J, Krithika S, Candille S, Lu Y, Manichakul A,Peralta-Romero J, Duan Q, Li Y, Morris AP, Gottesman O, Bottinger E, Wang XQ, Taylor2

Yun LiCurriculum VitaeFebruary 20, 2017KD, Ida Chen YD, Rotter JI, Rich SS, Loos RJ, Tang H, Cox NJ, Cruz M, Hanis CL,Valladares-Salgado A (2016) Meta-analysis of lipid-traits in Hispanics identifies novel loci,population-specific effects, and tissue-specific enrichment of eQTLs. Scientific Reports6:19429. PMID: 26780889. PMCID: PMC4726092.8. Urrutia E, Lee S, Maity A, Zhao N, Shen J, Li Y, Wu MC (2015) Rare variant testing acrossmethods and thresholds using the multi-kernel sequence kernel association test (MKSKAT). Stat Interface 8(4):495-505. PMID: 26740853. PMCID: PMC4698916.9. Fan R, Wang Y, Chui CY, Chen W, Ren H, Li Y, Boehnke M, Amos CI, Moore JH, Xiong M(2015) Meta-analysis of Complex Diseases at Gene Level with Generalized FunctionalLinear Models. Genetics 202(2): 457-70. PMID: 26715663. PMCID: PMC4788228.10. Lange EM, Ribado J, Zuhlke KA, Johnson A, Keele G, Li J, Wang Y, Duan Q, Li G, Gao Z,Li Y, Xu J, Zheng SL, Cooney KA (2015) Assessing the Cumulative Contribution of Newand Established Common Genetic Risk Factors to Early-Onset Prostate Cancer. CancerEpidemiol Biomarkers Prev. 25(5): 766-72. PMID: 26671023. PMCID: PMC4873425.11. Xu Z, Zhang G, Jin F, Chen M, Furey TS, Sullivan PF, Qin Z, Hu M#, Li Y# (2015) A hiddenMarkov random field-based Bayesian method for the detection of long-range chromosomalinteractions in Hi-C data. Bioinformatics 32(5):650-6. PMID: 26543175.12. The 1000 Genomes Project Consortium (2015) A global reference for human geneticvariation. Nature 526(7571):68-74. PMID: 26432245. PMCID: PMC4750478.13. Li J, Lange LA, Sabourin J, Duan Q, Valdar W, Willis MS, Li Y, Wilson JG, Lange EM(2015) Genome- and exome-wide association study of serum lipoprotein (a) in the JacksonHeart Study. J Hum Genet. 60(12):755-61. PMID: 26377243.14. Yuan S, Johnston HR, Zhang G, Li Y, Hu YJ, Qin ZS (2015) One Size Doesn't Fit All RefEditor: Building Personalized Diploid Reference Genome to Improve Read Mapping andGenotype Calling in Next Generation Sequencing Studies. PLoS Computational Biology11(8):e1004448. PMID: 26267278. PMCID: PMC4534450.15. Buchkovich ML, Eklund K, Duan Q, Li Y, Mohlke KL, Furey TS (2015) Removing referencemapping biases using limited or no genotype data identifies allelic differences in proteinbinding at disease-associated loci. BMC Med Genomics 8:43. PMID: 26210163. PMCID:PMC4515314.16. Lanktree MB, Elbers CC, Li Y, Zhang G, Duan Q, Karczewski KJ, Guo Y, Tragante V,North KE, Cushman M, Asselbergs FW, Wilson JG, Lange LA, Drenos F, Reiner AP,Barnes MR, Keating BJ (2015) Genetic meta-analysis of 15,901 African Americansidentifies variation in EXOC3L1 is associated with HDL concentration. J Lipid Res.56(9):1781-6. PMID: 26199122. PMCID: PMC4548782.3

Yun LiCurriculum VitaeFebruary 20, 201717. Fan R, Wang Y, Boehnke M, Chen W, Li Y, Ren H, Lobach I, Xiong M (2015) Gene LevelMeta-Analysis of Quantitative Traits by Functional Linear Models. Genetics 200(4):1089104. PMID: 26058849. PMCID: PMC4574252.18. Yan S, Yuan S, Xu Z, Zhang B, Zhang B, Kang G, Byrnes A, Li Y# (2015) Likelihood-basedcomplex trait association testing for arbitrary depth sequencing data. Bioinformatics31(18):2955-62. PMID: 25979475. PMCID: PMC4668777.19. Yu D, Zhang G, Huang X, Wu C, Tan W, Qiao Y, Chang J, Zhao H, Bi X, Cai J, Li Y#, Lin D(2015) Relatively Small Contribution of Methylation and Genomic Copy Number Aberrationto the Aberrant Expression of Inflammation-Related Genes in HBV-Related HepatocellularCarcinoma. PLoS One 10(5):e0126836. PMID: 25965583. PMCID: PMC4429029.20. Bi W, Kang G, Zhao Y, Cui Y, Yan S, Li Y, Cheng C, Pounds SB, Borowitz MJ, Relling MV,Yang JJ, Liu Z, Pui CH, Hunger SP, Hartford CM, Leung W, Zhang JF (2015) SVSI: Fastand Powerful Set-Valued System Identification Approach to Identifying Rare Variants inSequencing Studies for Ordered Categorical Traits. Ann Hum Genet. 79(4):294-309. PMID:25959545. PMCID: PMC4474746.21. Demerath EW, Guan W, Grove ML, Aslibekyan S, Mendelson M, Zhou YH, Hedman ÅK,Sandling JK, Li LA, Irvin MR, Zhi D, Deloukas P, Liang L, Liu C, Bressler J, Spector TD,North K, Li Y, Absher DM, Levy D, Arnett DK, Fornage M, Pankow JS, Boerwinkle E (2015)Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference inAfrican American adults identifies multiple replicated loci. Human Molecular Genetics24(15):4464-79. PMID: 25935004. PMCID: PMC4492394.22. Coram MA, Candille SI, Duan Q, Chan KH, Li Y, Kooperberg C, Reiner AP, Tang H (2015)Leveraging Multi-ethnic Evidence for Mapping Complex Traits in Minority Populations: AnEmpirical Bayes Approach. The American Journal of Human Genetics 96(5):740-52. PMID:25892113. PMCID: PMC4570551.23. Xu Z, Duan Q, Yan S, Chen W, Li M, Lange E, Li Y# (2015) DISSCO: direct imputation ofsummary statistics allowing covariates. Bioinformatics 31(15):2434-42. PMID: 25810429.PMCID: PMC4514926.24. Wang X, Zhang S, Li Y, Li M, Sha Q (2015) A powerful approach to test an optimallyweighted combination of rare variants in admixed populations. Genetic Epidemiology39(4):294-305. PMID: 25758547.25. Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P,Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, Rusyn I, Wright FA (2015)Population-based in vitro hazard and concentration-response assessment of chemicals: the1000 genomes high-throughput screening study. Environ Health Perspect 123(5):458-66.PMID: 25622337. PMCID: PMC4421772.4

Yun LiCurriculum VitaeFebruary 20, 201726. Hu YJ, Li Y, Auer PL, Lin DY (2015) Integrative analysis of sequencing and array genotypedata for discovering disease associations with rare mutations. Proc Natl Acad Sci U S A.112(4):1019-24. PMID: 25583502. PMCID: PMC4313847.27. Franceschini N, Hu Y, Reiner AP, Buyske S, Nalls M, Yanek LR, Li Y, Hindorff LA, ColeSA, Howard BV, Stafford JM, Carty CL, Sethupathy P, Martin LW, Lin DY, Johnson KC,Becker LC, North KE, Dehghan A, Bis JC, Liu Y, Greenland P, Manson JE, Maeda N,Garcia M, Harris TB, Becker DM, O'Donnell C, Heiss G, Kooperberg C, Boerwinkle E(2015) Prospective associations of coronary heart disease loci in African Americans usingthe MetaboChip: the PAGE study. PLoS One 9(12):e113203. PMID: 25542012. PMCID:PMC4277270.28. Huang KC, Sun W, Wu Y, Chen M, Mohlke, Lange LA, Li Y# (2014) Association studieswith imputed variants using expectation-maximization likelihood-ratio tests. PLoS One9(11):e110679. PMID: 25383782. PMCID: PMC4226494.29. Li J, Lange LA, Duan Q, Lu Y, Singleton AB, Zonderman AB, Evans MK, Li Y, Taylor HA,Willis MS, Nalls M, Wilson JG, Lange EM (2015) Genome-wide admixture and associationstudy of serum iron, ferritin, transferrin saturation and total iron binding capacity in AfricanAmericans. Human Molecular Genetics 24(2):572-581. PMID: 25224454. PMCID:PMC4334832.30. Ma Y, Zhao J, Wong JS, Ma L, Li W, Fu G, Xu W, Zhang K, Kittles RA, Li Y, Song Q (2014)Accurate inference of local phased ancestry of modern admixed populations. ScientificReports 4:5800. PMID: 25052506. PMCID: PMC4107375.31. Lange EM, Johnson AM, Wang Y, Zuhlke KA, Lu Y, Ribado JV, Keele GR, Li J, Duan Q, LiG, Gao Z, Li Y, Xu J, Isaacs WB, Zheng S, Cooney KA (2014) Genome-wide associationscan for variants associated with early-onset prostate cancer. PLoS One 9(4):e93436.PMID: 24740154. PMCID: PMC3989171.32. Han B, Luo H, Raelson J, Huang J, Li Y, Tremblay J, Hu B, Qi S, Wu J (2014) TGFBI (βIGH3) is a diabetes-risk gene based on mouse and human genetic studies. Hum Mol Genet.23(17):4597-611. PMID: 24728038. PMCID: PMC4119410.33. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium (2014)Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture oftype 2 diabetes susceptibility. Nature Genetics 46(3):234-44. PMID: 24509480. PMCID:PMC3969612. (I worked on performing imputation and analysis for the FUSION cohorts.)34. Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang ZZ, Bizon C, Lange EM, Smith JD,Turner EH, Jun G, Kang HM, Peloso G, Auer P0, Li KP, Flannick J, Zhang J, FuchsbergerC, Gaulton K, Lindgren C, Locke A, Manning A, Sim X, Rivas MA, Holmen OL, GottesmanO, Lu Y, Ruderfer D, Stahl EA, Duan Q, Li Y, Durda P, Jiao S0, Isaacs A, Hofman A, BisJC, Correa A, Griswold ME, Jakobsdottir J, Smith AV, Schreiner PJ, Feitosa MF, Zhang Q,Huffman JE, Crosby J0, Wassel CL, Do R, Franceschini N, Martin LW, Robinson JG,5

Yun LiCurriculum VitaeFebruary 20, 2017Assimes TL, Crosslin DR, Rosenthal EA, Tsai M, Rieder MJ, Farlow DN, Folsom AR,Lumley T, Fox ER, Carlson CS0, Peters U0, Jackson RD0, van Duijn CM, Uitterlinden AG,Levy D, Rotter JI, Taylor HA, Gudnason V Jr, Siscovick DS, Fornage M, Borecki IB,Hayward C, Rudan I, Chen YE, Bottinger EP, Loos RJ, Sætrom P, Hveem K, Boehnke M,Groop L, McCarthy M0, Meitinger T, Ballantyne CM, Gabriel SB, O'Donnell CJ, Post WS,North KE, Reiner AP, Boerwinkle E0, Psaty BM, Altshuler D, Kathiresan S, Lin DY, JarvikGP0, Cupples LA, Kooperberg C0, Wilson JG, Nickerson DA, Abecasis GR, Rich SS, TracyRP, Willer CJ; NHLBI Grand Opportunity Exome Sequencing Project (2014) Whole-exomesequencing identifies rare and low-frequency coding variants associated with LDLcholesterol. The American Journal of Human Genetics 94(2):233-45. PMID: 24507775.PMCID: PMC3928660. (I helped with quality control and rare variant association analysis ofthe